San Francisco was a city on the planet Earth. It was famous for it's high crime rate and military bases. One notable person born in the city was John DeMarcus. The city also had tall buildings and sections that were made for refugees from other countries.
After the human species were discovered by other galactic organisms, several major cities rose in population and became large trading hub. San Francisco, along with several other American cities, were among the hubs. With all the gained money, San Francisco built taller, larger buildings. The city was home to the headquarters of Vapor Industries.
The cities crime had lowered after Earth was discovered, this was a result of high class criminals leaving the city in order find money elsewhere.